- Projects, Research

The IGTP participates in a pioneer EU project to investigate micro and nanoplastics impact and consequences on human health

PLASTICHEAL project will develop new methodologies and will provide reliable scientific evidence for regulators to set the knowledge basis for adequate risk assessment. The results will draw a variety of experimental human models and measuring potential health effects under short and long-term conditions. The researchers at the IGTP will focus on the study of the affect of plastics to the immune response to different microorganisms.

- Research

A new study shows that multiple infections are common with multiple drug resistant tuberculosis

The IGTP has taken part in a study led by researchers from the IBV Biomedicine Institute of Valencia  published recently in Nature Communications. The study has increased the understanding of how genetic diversity arises in lung infections caused by Mycobacterium tuberculosis and how this is related to the development of antibiotic resistant variants. The study is based on surgical samples and data from tuberculosis patients form the SH-TBL cohort of the Experimental Tuberculosis Group (UTE) at the IGTP.

- Research

Research identifies six groups in the population more susceptible to the impact of the pandemic

Researchers from the Experimental Tuberculosis Unit (UTE) led by Dr Cristina Vilaplana, have presented the results of the project COM-COVID, a questionnaire for the public aimed at understanding the effects of the pandemic on society. The COM-COVID is an initiative of the SMA-TB Consortium, led by the UTE and the IGTP, with the collaboration of the Sant Joan de Déu Research Institute and the Fight AIDS Foundation. Dr Maria Rosa Sarrias from the Innate Immunity Group and Dr Carol Armengol of the c-LOG research group at the IGTP have also taken part. The results have been sent in a report by email to all the participants of the questionnaire who requested it, and the research article can also be consulted at medRxiv.

- Research

An electronic alert for primary healthcare will make improved HIV testing possible

Researchers from the IDIAP Jordi Gol Foundation, CEEISCAT and the IGTP have shown that a strategy to improve early detection of HIV by primary healthcare providers is effective. When a patient is diagnosed with an illness or group of symptoms which could be related to HIV, an alert appears on the screen of the doctor attending in the form of a pop-up, which recommends a blood test. The results of the project, which have been presented at the international conference HepHIV, show that primary healthcare centres with the system in place are detecting 50% more positive cases than those which don't.

- Research

Advancing sequencing and computational methods to identify genetic and phenotypic variations in Staphylococcus aureus from patients on mechanical ventilation

The Innovation in Respiratory Infections and Tuberculosis Diagnosis Group have used powerful genomics and computational tools to look at the genomes and phenotypes of Staphylococcus aureus isolated from patients on mechanical ventilation, suffering from different types of infection. The study, published in Toxins, identifies differences that could help doctors better manage patients with S. aureus infections in the future

- Research

Researchers identify mutations acquired by blood cells that accelerate heart failure progression

A study published in The Journal of the American College of Cardiology shows that clonal haematopoiesis is an important pathological process that accelerates and aggravates the clinical progression of heart failure, independently of the presence of atherosclerosis. The researchers of the Heart Disease Research Group the IGTP have participated in the study, led by the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Hospital Universitario Virgen de Arrixaca in Murcia. 

- Research

A dietary supplement of betaine for mothers during lactation can reduce the risk of childhood obesity

A research group led by the Sant Joan de Déu Research Institute, with the participation of the IGTP, has shown that reduced levels of betaine in maternal milk are associated with more rapid growth of the baby during the first months of life, this is a risk factor for childhood obesity. The researchers have studied the changes in the presence of this nutrient in animal models and have observed temporary changes in the intestinal microbiota and long-term changes in their metabolic health.

- Research

Biomaterial scaffolds containing extracellular vesicles from stem cells to control and promote heart muscle repair after heart attack

Scientists of the ICREC group at the Germans Trias i Pujol Research institute (IGTP) continue to refine their technology for repairing cardiac tissue after a heart attack.  In a paper published in Bioactive Materials they present their latest work in which they use implanted scaffolds containing no cells, but extracellular vesicles that promote the repair of myocardium damaged in a heart attack.